CYP2A6

Description

Please note that the content of this book primarily consists of articles
available from Wikipedia or other free sources online. Cytochrome P450
2A6 (abbreviated CYP2A6) is a member of the cytochrome P450
mixed-function oxidase system, which is involved in the metabolism of
xenobiotics in the body. CYP2A6 is the primary enzyme responsible for
the oxidation of nicotine and cotinine. It is also involved in the
metabolism of several pharmaceuticals, carcinogens, and a number of
coumarin-type alkaloids. CYP2A6 is the only enzyme in the human body
that appreciably catalyzes the 7-hydroxylation of coumarin, such that
the formation of the product of this reaction, 7-hydroxycoumarin, is
used as a probe for CYP2A6 activity.